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Senescence Marker Reversal

Meaning

Senescence Marker Reversal is the measurable reduction or effective elimination of specific molecular and cellular indicators associated with cellular senescence, which is a state of irreversible cell cycle arrest that cells enter in response to accumulated stress or DNA damage. Senescent cells pathologically accumulate with advancing age, secrete a pro-inflammatory mixture known as the Senescence-Associated Secretory Phenotype (SASP), and actively drive chronic inflammation and tissue dysfunction throughout the body. Achieving marker reversal is a primary and essential goal of senolytic and senomorphic therapies designed to rejuvenate tissues, restore function, and improve systemic health.