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Senescence Hyposomatotropism Reversal

Meaning

Senescence Hyposomatotropism Reversal is a clinical intervention strategy aimed at restoring the declining activity of the somatotropic axis, characterized by reduced pulsatile secretion of Growth Hormone (GH) and subsequent lower levels of Insulin-like Growth Factor 1 (IGF-1), which is a hallmark of biological aging. This reversal seeks to mitigate the adverse consequences of age-related GH deficiency, including sarcopenia, increased visceral adiposity, and reduced bone mineral density, thereby promoting an anabolic state and improving overall tissue vitality. The goal is to re-establish a youthful GH/IGF-1 signaling profile.