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Senescence Deceleration

Meaning

Senescence Deceleration is the clinical objective of slowing the rate at which cells and tissues enter the state of cellular senescence, a permanent state of cell cycle arrest that contributes significantly to aging and chronic disease. Senescent cells, often termed “zombie cells,” accumulate with age, secrete pro-inflammatory molecules (the Senescence-Associated Secretory Phenotype or SASP), and disrupt the function of surrounding healthy tissue. Deceleration protocols aim to reduce the burden of these dysfunctional cells and maintain a youthful proliferative capacity in healthy cells. This strategy is a core tenet of modern longevity medicine and anti-aging research.