What is the Origin of Senescence Clearance Protocols?

The concept emerged from the field of gerontology and cellular biology, following the identification of senescent cells as key contributors to the aging phenotype. The development of senolytic agents and targeted interventions gave rise to the idea of a structured protocol for clearance.

What is the Mechanism of Senescence Clearance Protocols?

Protocols primarily involve the use of senolytic compounds, which induce apoptosis specifically in senescent cells by targeting their pro-survival pathways. Other strategies include intermittent fasting or specific exercise modalities that enhance the body's natural mechanisms for clearing damaged cells. By reducing the inflammatory load from senescent cells, these protocols can potentially restore tissue microenvironments, thereby supporting the function of local endocrine cells and improving systemic health.

Senescence Clearance Protocols ∞ Area

Senescence Clearance Protocols

Meaning

Therapeutic or lifestyle strategies specifically designed to promote the selective elimination of senescent cells—aged, non-dividing cells that accumulate in tissues and secrete a pro-inflammatory secretome (SASP). These protocols aim to reduce the burden of cellular senescence, which is a major driver of chronic inflammation, tissue dysfunction, and age-related hormonal decline.