Semax and Selank are two distinct synthetic peptides primarily recognized for their nootropic and anxiolytic properties, respectively, which exert their effects through modulation of the central nervous system. Semax is an analog of a fragment of adrenocorticotropic hormone (ACTH) and is often used to enhance cognitive function and neuroprotection. Selank is an analog of the body’s natural immunomodulatory peptide, tuftsin, and is utilized for its potent anti-anxiety and mood-stabilizing effects. While acting centrally, their impact on stress and cognitive load has indirect, positive implications for the HPA axis and overall hormonal health.
Origin
Both peptides were developed and researched extensively in Russia, stemming from targeted investigations into the therapeutic potential of endogenous regulatory peptides. Their origin lies in the field of neuro-peptidomics and psychopharmacology, aiming to create compounds with high efficacy and low systemic side effects. Their clinical application has expanded beyond neurology to integrated wellness due to the recognized link between neurocognitive health and systemic endocrine balance. They represent a class of highly specific, short-chain peptide therapeutics.
Mechanism
Semax is believed to work by increasing the expression of neurotrophins, such as Brain-Derived Neurotrophic Factor (BDNF), which promotes synaptic plasticity and neuronal survival. Selank primarily functions by modulating the balance of monoamine neurotransmitters and increasing the stability of endogenous enkephalins, which are involved in pain and stress regulation. The indirect mechanism relevant to hormonal health is the reduction of psychological stress, which lessens the chronic burden on the HPA axis and helps to normalize cortisol patterns. This neuro-modulation supports a favorable environment for Endocrine Health Optimization.
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