Semax Peptide Therapy involves the clinical administration of Semax, a synthetic heptapeptide derived from a fragment of the adrenocorticotropic hormone (ACTH), primarily used for its nootropic, neuroprotective, and neurogenic properties. This therapeutic agent is utilized to enhance cognitive function, improve memory and attention, and support recovery from cerebral ischemia or neurological stress. It is a targeted intervention within advanced neuro-optimization protocols.
Origin
Semax was developed by the Russian Institute of Molecular Genetics and is rooted in the study of neuropeptides and their profound influence on the central nervous system. Its origin as a fragment of ACTH highlights the long-standing understanding of the pituitary axis’s role in cognitive and stress response. The clinical application as a “Peptide Therapy” emphasizes its targeted, signaling-based mechanism of action.
Mechanism
Semax operates primarily by upregulating the expression of Brain-Derived Neurotrophic Factor (BDNF) and other neurotrophins in the hippocampus and cortex, promoting synaptogenesis and neuronal survival. Furthermore, it modulates the activity of neurotransmitters like dopamine and serotonin, enhancing synaptic transmission and improving attention and mood regulation. The peptide is typically administered intranasally for rapid and efficient access to the central nervous system.
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