Semax Nasal Spray refers to the pharmaceutical delivery form of Semax, a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) sequence, which is clinically utilized for its pronounced nootropic and neuroprotective effects. Administered via nasal spray, this route bypasses the gastrointestinal tract and the blood-brain barrier with high efficiency, allowing the peptide to rapidly engage central nervous system targets. It is clinically applied to enhance cognitive function, memory consolidation, and to support recovery from conditions involving cerebral ischemia. The peptide is primarily recognized for its ability to modulate neurotrophic factors and neurotransmitter activity.
Origin
Semax was developed by the Institute of Molecular Genetics of the Russian Academy of Sciences and has been in clinical use in some countries for decades, primarily for its neurobiological benefits. The nasal spray formulation was specifically engineered to maximize bioavailability to the brain, recognizing the limitations of oral peptide delivery. Its origin as a fragment of ACTH highlights the long-standing interest in utilizing endogenous hormone sequences for targeted therapeutic action in the nervous system. The drug’s design reflects precision pharmacology.
Mechanism
Semax’s primary mechanism of action involves the selective upregulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the central nervous system, promoting neurogenesis and synaptic plasticity. The peptide also interacts with specific brain receptors, including those for enkephalins, and modulates the metabolism of monoamines like serotonin and dopamine. By enhancing the expression of these critical neurotrophic factors, Semax supports the survival of neurons, improves communication between brain cells, and facilitates the adaptive processes underlying learning and memory.
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