Semax Applications denote the specific clinical and therapeutic uses of the synthetic peptide Semax, which is a potent heptapeptide analog of the adrenocorticotropic hormone (ACTH) fragment ACTH(4-10). Its primary applications are focused on leveraging its powerful nootropic and neuroprotective capabilities, including enhancing memory consolidation, significantly improving sustained attention, and providing robust neuroprotection against various forms of cerebral ischemia. This peptide is clinically utilized in specific regions for the management of cognitive deficits and for supporting recovery following acute neurological events.
Origin
Semax was developed by Russian researchers at the Institute of Molecular Genetics, representing a significant achievement in rational drug design by modifying a naturally occurring hormone fragment to enhance its stability and central nervous system bioavailability. The term “Applications” simply outlines the diverse clinical scenarios where its unique neurobiological activity is therapeutically employed.
Mechanism
The mechanism of Semax is largely attributed to its ability to dramatically increase the expression of key neurotrophic factors, specifically Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF), within the central nervous system. This upregulation actively promotes neurogenesis, enhances synaptogenesis, and supports the survival of existing neurons. Additionally, Semax has been demonstrated to modulate the activity of the enkephalinergic and serotonergic systems, which contributes to its overall cognitive-enhancing and stress-modulating effects without exhibiting the peripheral endocrine activity of the complete ACTH molecule.
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