What is the Origin of Semax and Selank Effects?

Both peptides were developed by the Russian Institute of Molecular Genetics, initially as pharmaceutical agents for clinical use in neurological and psychiatric disorders. Their development was driven by the goal of creating stable, potent analogs of endogenous regulatory peptides. This research focused on optimizing the bioavailability and targeted action of naturally occurring neuro-modulators.

What is the Mechanism of Semax and Selank Effects?

Semax is believed to work by increasing the expression of brain-derived neurotrophic factor (BDNF) and modulating the levels of monoamine neurotransmitters, thereby promoting synaptic plasticity and neuronal survival. Selank primarily acts as a modulator of the GABAA receptor complex and influences the metabolism of enkephalins, resulting in a pronounced reduction of anxiety and stabilization of emotional responses without sedative effects. Their combined effects target both cognitive performance and emotional regulation.

Semax and Selank Effects ∞ Area

Semax and Selank Effects

Meaning

Semax and Selank Effects refer to the observed neurological and physiological outcomes following the administration of these two synthetic peptide analogs, which are clinically recognized primarily for their nootropic and anxiolytic properties. Semax, a heptapeptide fragment of ACTH, is known for enhancing cognitive function and neuroprotection, while Selank, a tuftsin analog, is primarily used for its robust anti-anxiety and mood-stabilizing effects. Both peptides modulate the neuroendocrine system to promote central nervous system homeostasis.