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Semaglutide Tolerance

Meaning

Semaglutide Tolerance refers to the clinical state where a patient’s body has successfully adapted to the chronic presence of the GLP-1 receptor agonist medication, Semaglutide, which is typically characterized by a significant reduction in the severity and frequency of the initial gastrointestinal side effects. It can also, less commonly, refer to a phenomenon of diminished therapeutic response over an extended period, which may necessitate a dose escalation or a strategic change in the treatment protocol. Achieving and maintaining good tolerance is a key clinical goal for maximizing patient adherence and ensuring long-term efficacy in the management of type 2 diabetes and obesity.