What is the Origin of Semaglutide Overdose?

This term is a specific clinical toxicology classification arising from the drug's powerful and long-acting mechanism as a glucagon-like peptide-1 receptor agonist. The potential for a sustained, excessive effect due to its long half-life necessitates a specific clinical protocol for managing an overdose event.

What is the Mechanism of Semaglutide Overdose?

A supraphysiological concentration of Semaglutide profoundly activates the GLP-1 receptor, resulting in an excessive, glucose-dependent stimulation of insulin secretion and a significant suppression of glucagon release. This potent combined action drives blood glucose down precipitously, causing severe hypoglycemia that is difficult to reverse due to the drug's extended half-life. Furthermore, the excessive agonism leads to severe inhibition of gastric motility and central stimulation of the chemoreceptor trigger zone, causing profound GI distress.

Semaglutide Overdose ∞ Area

Semaglutide Overdose

Meaning

The acute administration of a Semaglutide dose that substantially exceeds the prescribed therapeutic amount, leading to an exaggerated and potentially hazardous pharmacological response. This event is a clinical emergency primarily due to the significant risk of severe, prolonged hypoglycemia and intense, intractable gastrointestinal symptoms such as nausea and vomiting. Management of Semaglutide overdose requires immediate clinical intervention and continuous supportive care to stabilize the patient’s metabolic state.