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Semaglutide Muscle Loss

Meaning

Semaglutide Muscle Loss refers to the clinically observed phenomenon of a significant reduction in lean body mass (LBM), specifically skeletal muscle, that can accompany the substantial weight loss induced by the GLP-1 receptor agonist semaglutide. While the drug effectively reduces appetite and improves glycemic control, the rapid and significant caloric deficit often triggers a catabolic state that disproportionately affects muscle tissue alongside fat mass. This loss of LBM is a critical clinical concern because it compromises long-term metabolic health, strength, and overall longevity.