What is the Origin of Semaglutide for Body Composition?

Semaglutide is a synthetic analog of Glucagon-like Peptide-1 (GLP-1), a naturally occurring incretin hormone discovered in the 1980s. Its application for body composition stems from large-scale clinical trials demonstrating substantial, sustained weight loss, which inherently leads to favorable changes in body composition metrics. The clinical focus shifted rapidly following these compelling efficacy data.

What is the Mechanism of Semaglutide for Body Composition?

Semaglutide activates GLP-1 receptors in the pancreas to enhance glucose-dependent insulin secretion and in the brain to increase satiety and reduce food intake. Crucially, it also delays gastric emptying, further contributing to reduced caloric consumption. The resulting sustained energy deficit leads to the mobilization of stored triglycerides, preferentially reducing fat mass while preserving lean muscle tissue, especially when combined with resistance training.

Semaglutide for Body Composition ∞ Area

Semaglutide for Body Composition

Meaning

Semaglutide for Body Composition refers to the clinical use of the GLP-1 receptor agonist Semaglutide, primarily for its beneficial effects on reducing visceral adiposity and improving the ratio of lean mass to fat mass. While initially developed for type 2 diabetes, its potent action on appetite regulation and metabolic function makes it a significant tool for managing weight and enhancing overall physical structure. This therapeutic application is distinct from its glucose-lowering role.