The state where an individual’s internal biological systems maintain autonomous, appropriate regulation of their own setpoints and signaling without undue interference from chronic external disruptors or persistent suboptimal internal feedback. It implies robust physiological independence and resilience. This is functional self-governance at the cellular level.
Origin
This is a conceptual term reflecting an ideal state of physiological autonomy, often discussed in holistic and personalized health circles. It borrows the political concept of sovereignty to describe an organism’s ability to defend its own optimal internal environment against dysregulation. It champions inherent biological wisdom.
Mechanism
This sovereignty is maintained through highly responsive, negative feedback loops within the endocrine system, such as the HPG and HPT axes, which resist external noise. It requires cellular integrity to ensure receptors respond accurately to endogenous signals, thereby preventing pathological drift. When self-sovereignty is achieved, systemic stability becomes the default state, independent of minor environmental perturbations.
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