Self-Repair Mechanisms refer to the complex, evolutionarily conserved cellular and molecular processes that the body innately employs to detect, correct, and mitigate damage at the DNA, protein, and organelle levels. These mechanisms include DNA repair pathways, chaperone-mediated protein folding, and autophagy for organelle clearance. The functional capacity of these systems is a direct determinant of healthspan, resilience, and the rate of biological aging.
Origin
This term is a broad, translational concept encompassing fundamental biological processes discovered across genetics, cell biology, and biochemistry. It is rooted in the understanding that life is a continuous struggle against entropy and damage accumulation. Clinical and wellness applications focus on optimizing, rather than replacing, these inherent maintenance systems.
Mechanism
Key self-repair pathways are often activated by mild cellular stress, a principle known as hormesis. For example, intermittent fasting activates autophagy, clearing damaged mitochondria and proteins. Hormones, such as DHEA and growth hormone, also play a supportive role in promoting the synthesis of repair enzymes and growth factors. By consistently engaging and supporting these innate systems, the body maintains cellular and tissue integrity against chronic wear and tear.
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