Self-Regulation Chemistry encompasses the integrated network of neuroendocrine and autonomic processes responsible for maintaining internal stability (allostasis) across fluctuating internal and external conditions. This involves the dynamic feedback control of the HPA axis, autonomic balance (sympathetic/parasympathetic tone), and metabolic flux. Effective self-regulation ensures adaptive physiological responses without chronic resource depletion.
Origin
This concept integrates endocrinology with psychophysiology, focusing on the chemical basis of internal control systems. Its origin is in understanding how the body chemically manages stress and maintains equilibrium beyond simple set points. It describes the active chemical maintenance of homeostasis.
Mechanism
The primary mechanism involves the negative feedback loop of the HPA axis, where circulating cortisol modulates CRH and ACTH release to terminate the stress response appropriately. Furthermore, proper autonomic balance ensures efficient resource allocation, preventing the chronic activation of catabolic pathways. Optimal thyroid function supports the overall metabolic rate required for these regulatory processes to function efficiently.
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