What is the Origin of Self-Emulsifying Drug Delivery System?

This technology originated in pharmaceutical science and drug formulation, driven by the challenge of improving the absorption of hydrophobic drug molecules. The term combines the self-acting nature of the emulsion formation, "self-emulsifying," with the purpose, "drug delivery system." It represents a key innovation in overcoming physicochemical limitations to drug absorption, thereby improving therapeutic outcomes for difficult-to-deliver compounds.

What is the Mechanism of Self-Emulsifying Drug Delivery System?

The core mechanism relies on the pre-dissolution of the drug in the oily phase, which bypasses the slow dissolution step typically required for solid oral dosage forms. Once the emulsion forms tiny droplets (nanosized), the large interfacial surface area facilitates rapid partitioning of the drug into the aqueous environment. Furthermore, the surfactants and oils can stimulate lymphatic transport or inhibit efflux pumps in the intestinal wall, collectively enhancing the systemic absorption and reducing first-pass metabolism, leading to a more predictable and higher plasma concentration.

Self-Emulsifying Drug Delivery System ∞ Area

Self-Emulsifying Drug Delivery System

Meaning

A Self-Emulsifying Drug Delivery System (SEDDS) is an advanced pharmaceutical formulation consisting of a drug dissolved in an isotropic mixture of oils, surfactants, and co-solvents. Upon contact with the aqueous environment of the gastrointestinal tract, this system spontaneously forms a fine, stable emulsion. The primary clinical utility of SEDDS is to significantly enhance the oral bioavailability of highly lipophilic, poorly water-soluble drugs, including many steroid hormones and specific peptide analogs.