Question 1

What is the Meaning of Selectivity Index?

Accepted Answer

The Selectivity Index (SI) is a critical quality control metric used during Adrenal Vein Sampling (AVS) to verify that the blood sample collected via the catheter is truly from the adrenal vein and not merely a diluted sample from the surrounding systemic circulation. It is a necessary calculation to ensure the technical success and diagnostic accuracy of the procedure. An acceptable SI is paramount for the reliable interpretation of the Lateralization Index.

Question 2

What is the Origin of Selectivity Index?

Accepted Answer

This is a specialized clinical index derived from the AVS procedure, designed to measure the Selectivity or purity of the blood sample collected from the adrenal vein. The Index is the ratio used to quantify this purity. The term is integral to the standardized protocol for diagnosing unilateral aldosterone excess.

Question 3

What is the Mechanism of Selectivity Index?

Accepted Answer

The index is calculated by dividing the cortisol concentration measured in the adrenal vein sample by the cortisol concentration measured in a peripheral vein sample, such as the inferior vena cava. Since cortisol is secreted in high concentration by the adrenal glands, a value significantly greater than one confirms that the catheter tip is correctly positioned within the adrenal vein, as opposed to a less selective position. This verification step ensures the accuracy of the subsequent aldosterone measurements.

Selectivity Index

Meaning

Origin

Mechanism

What Clinical Tests Precisely Assess Adrenal Response to Sodium Levels?

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