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Selective Modulation

Meaning

Selective Modulation is a precise pharmacological strategy involving the design of therapeutic agents that interact with specific subtypes or isoforms of a hormone receptor to elicit a desired action in one target tissue while simultaneously minimizing or blocking effects in other tissues. This approach allows clinicians to harness the beneficial actions of a hormone, such as estrogen’s effect on bone density, while mitigating potential adverse effects on other organs, such as the endometrium. This targeted action is a hallmark of modern precision endocrinology.