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Selective GH Secretagogues

Meaning

Selective GH Secretagogues (GHSs) are a class of synthetic compounds that specifically stimulate the pulsatile release of endogenous Growth Hormone (GH) from the pituitary gland by acting on distinct receptors in the hypothalamus and pituitary. These agents are considered “selective” because their primary mechanism is to amplify the natural, rhythmic secretion of GH, often without significantly affecting the secretion of other pituitary hormones like prolactin or cortisol at therapeutic doses. This targeted action is a key clinical advantage, offering a way to restore more youthful patterns of GH release for benefits in tissue repair and metabolic function.