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Selective Estrogen Receptor Antagonist

Meaning

A Selective Estrogen Receptor Antagonist (SERA) is a class of therapeutic compounds that binds to estrogen receptors (ERs) in various tissues, acting to block the effects of endogenous estrogen in a tissue-specific manner. Unlike a pure antagonist, a SERA exhibits a mixed profile, functioning as an antagonist in some tissues, such as the breast or hypothalamus, while potentially acting as an agonist in others, like bone. This selectivity allows for targeted hormonal modulation, offering therapeutic benefits while minimizing undesirable estrogenic effects in sensitive tissues.