Selank Anxiolytic refers to the anxiety-reducing property of the synthetic peptide Selank, which is derived from a naturally occurring human immunomodulatory peptide. This heptapeptide is clinically utilized to mitigate symptoms of generalized anxiety and stress without causing the sedative or addictive side effects commonly associated with traditional anxiolytic medications. It is considered a non-benzodiazepine agent for managing emotional and cognitive stress responses.
Origin
Selank was developed by the Institute of Molecular Genetics of the Russian Academy of Sciences in the late 20th century as a therapeutic agent with both anxiolytic and nootropic properties. The term ‘Anxiolytic’ is a pharmacological classification for substances that inhibit anxiety.
Mechanism
The peptide’s mechanism of action is primarily mediated by its influence on the brain’s endogenous regulatory systems, specifically by modulating the metabolism and expression of GABA and serotonin. Selank is known to inhibit the degradation of enkephalins, which are natural opioid peptides, and to modulate the activity of the benzodiazepine-GABA-receptor complex in the central nervous system.
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