The modulation or amelioration of symptoms associated with anxiety disorders through the application of Selank, a synthetic derivative peptide known for its anxiolytic properties, often investigated for its effects on the central nervous system’s stress response pathways. This targets maladaptive fear circuits.
Origin
Selank, or a Tuftsin analogue, originates from Russian psychopharmacology research, where it was developed to target specific components of the anxiety cascade without significant sedative side effects common to other agents. Its nomenclature reflects its synthetic origin and intended therapeutic application in managing stress.
Mechanism
The proposed mechanism involves influencing the balance of neurotransmitters, potentially by interacting with GABAergic systems or modulating the release of specific neuropeptides that regulate fear and stress pathways in the limbic system. It appears to stabilize the HPA axis response to stressors, preventing the pathological hypersecretion of glucocorticoids associated with chronic anxiety states. This stabilization supports a return to neuroendocrine homeostasis.
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