Selank and Semax are synthetic peptide analogues developed primarily for their purported nootropic and anxiolytic properties, often utilized in research settings to investigate cognitive and neurological resilience beyond standard endocrine modulation. While not classic hormonal agents, their impact on stress pathways indirectly relates to the HPA axis function by influencing neurotransmitter systems crucial for stress coping.
Origin
These compounds originate from Russian psychopharmacology research, designed as modified fragments of endogenous peptides to enhance cognitive function and neuroprotection. Their study represents an exploration into targeted neurochemical enhancement.
Mechanism
Semax is often proposed to act as a substrate for the enzyme dipeptidyl peptidase-IV, potentially increasing endogenous levels of certain neuropeptides, while Selank is thought to modulate GABAergic neurotransmission, leading to reduced anxiety. By stabilizing central nervous system excitability, they may indirectly support the maintenance of healthy peripheral endocrine signaling under stress.
Lifestyle interventions create the necessary biological stability for targeted peptide protocols to effectively recalibrate the body's stress response systems.
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