Selank is a synthetic anxiolytic peptide, structurally analogous to the endogenous human tetrapeptide tuftsin, which has been studied for its potential nootropic and anti-anxiety effects. It is classified as a synthetic analog of a human immunomodulatory peptide, often used clinically to manage generalized anxiety disorder and improve cognitive function. Its action is distinct from classical benzodiazepines, offering an alternative approach to mood and stress management.
Origin
Selank was developed by the Institute of Molecular Genetics of the Russian Academy of Sciences in the early 2000s as a derivative of tuftsin, focusing on enhancing its stability and biological activity in the central nervous system. Its development was driven by the need for an effective anxiolytic agent with minimal sedative or addictive properties.
Mechanism
The primary mechanism involves modulating the activity of the GABAergic system and influencing the metabolism of monoamine neurotransmitters like serotonin and dopamine. Selank has been shown to inhibit the enzymatic breakdown of enkephalins, endogenous opioid peptides, which contributes to its anxiolytic effects. Furthermore, it modulates the expression of brain-derived neurotrophic factor, thereby supporting neuroplasticity and enhancing cognitive performance under stress.
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