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Secondary Hypogonadism Signature

Meaning

Secondary Hypogonadism Signature refers to the specific, recognizable clinical and biochemical pattern of sex hormone deficiency characterized by low circulating levels of gonadal steroids, such as testosterone or estradiol, in the concurrent presence of inappropriately low or normal levels of the pituitary gonadotropins, Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). This signature definitively indicates a functional failure in the central regulatory control—the hypothalamus or the pituitary gland—rather than a primary, intrinsic failure of the gonads themselves. Identifying this distinct signature is absolutely critical for determining the correct etiology and subsequent, appropriate treatment strategy.