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SCN Calibration

Meaning

SCN Calibration refers to the clinical process of fine-tuning the intrinsic timing and output of the Suprachiasmatic Nucleus (SCN), the brain’s master circadian pacemaker, to achieve optimal, precise synchronization with the external environment and the internal hormonal rhythms. Effective calibration ensures the accurate timing of critical physiological events, such as the robust cortisol awakening response and the appropriate nocturnal melatonin secretion onset. This process is crucial for maintaining a resilient, robust hormonal architecture and preventing the metabolic consequences of circadian misalignment.