What is the Origin of Scalp Microinflammation?

This concept emerged from advanced dermatological and trichological research that moved beyond purely hormonal explanations for hair loss pathology. It identifies a crucial immunological and inflammatory component in the complex pathogenesis of hair disorders. The term describes a localized, subclinical inflammatory process that silently undermines follicular health and viability.

What is the Mechanism of Scalp Microinflammation?

The mechanism involves the chronic release of pro-inflammatory mediators, such as interleukins and tumor necrosis factor-alpha (TNF-α), from resident immune cells and stressed follicular cells. These cytokines create a hostile microenvironment that damages the delicate hair follicle stem cell niche and disrupts the critical anagen (growth) phase of the hair cycle. This persistent microinflammation can be triggered by oxidative stress, microbial imbalance, or chronic exposure to androgens, collectively leading to perifollicular fibrosis and the progressive atrophy of the hair follicle.

Scalp Microinflammation ∞ Area

Scalp Microinflammation

Meaning

Scalp Microinflammation refers to a chronic, subclinical, low-grade inflammatory state occurring within the connective tissues of the scalp, specifically localized around the hair follicles. This subtle, persistent inflammation is not always clinically visible as overt redness or scaling but is biochemically characterized by the sustained presence of inflammatory cytokines and immune cell infiltration in the dermal papilla area. Scalp microinflammation is a key pathological factor implicated in the miniaturization of hair follicles and the progressive development of various forms of non-scarring hair loss, including androgenetic alopecia.