What is the Meaning of Satiety Signals?

Satiety Signals are a diverse group of hormonal, neural, and mechanical cues that are generated during and after a meal to induce a feeling of fullness and terminate food intake. These signals act upon the hypothalamus and brainstem centers to regulate short-term energy balance and appetite control. Key endocrine signals include gut peptides like Cholecystokinin (CCK), Peptide YY (PYY), and Glucagon-like Peptide-1 (GLP-1), which are released from the gastrointestinal tract in response to nutrient presence. The proper function of these signals is crucial for preventing overeating and maintaining a healthy body weight.

What is the Origin of Satiety Signals?

The term "satiety" comes from the Latin satietas, meaning enough or full. The concept of specific signals regulating the cessation of eating emerged from mid-20th-century physiological research on the central control of feeding behavior. The subsequent identification and characterization of the gut-derived peptides in the late 20th and early 21st centuries solidified the molecular understanding of this intricate hormonal communication system.

What is the Mechanism of Satiety Signals?

The mechanism involves the release of gut hormones in proportion to the volume and nutrient composition of the ingested food. These hormones travel via the circulation or act on vagal afferent nerves to transmit information about gut filling and nutrient absorption to the brain's appetite centers. For example, GLP-1 and PYY bind to receptors in the arcuate nucleus of the hypothalamus, inhibiting the activity of orexigenic (appetite-stimulating) neurons and activating anorex

Satiety Signals ∞ Area ∞ Library 2

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