What is the Origin of Satiety Regulation?

"Satiety" comes from the Latin satietas, meaning "fullness" or "enough." "Regulation" denotes the control mechanism. The term describes the body's control over the sensation of being full and the termination of eating behavior.

What is the Mechanism of Satiety Regulation?

Following nutrient ingestion, specialized enteroendocrine cells in the gut release various anorexigenic (appetite-suppressing) hormones, including Cholecystokinin (CCK) and Glucagon-like Peptide-1 (GLP-1). These hormones travel via the bloodstream to the brain, where they act on receptors in the arcuate nucleus of the hypothalamus, promoting the activation of pro-opiomelanocortin (POMC) neurons. This signaling cascade ultimately inhibits feeding behavior and reduces meal size, maintaining energy homeostasis and preventing excessive caloric intake.

Satiety Regulation

Meaning

The complex neuroendocrine process governing the feeling of fullness and the suppression of hunger that occurs after a meal, which determines the interval before the next feeding episode. This crucial homeostatic mechanism involves a dynamic interplay of gut hormones, such as GLP-1 and PYY, and central nervous system signaling within the hypothalamus. Dysfunction in satiety regulation is a significant clinical factor contributing to chronic positive energy balance, weight gain, and the development of metabolic derangements, including insulin resistance.

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How Do Genetic Factors Affect Melanocortin Receptor Function?

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Satiety Regulation

Meaning

Origin

Mechanism

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How Do Lifestyle Changes Complement Semaglutide’s Metabolic Effects?

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How Do Genetic Factors Affect Melanocortin Receptor Function?

What Are the Specific Considerations for Combining GLP-1 Agonists with Hormonal Therapies?

Can Peptide Modulation Address Underlying Hormonal Imbalances Contributing to Weight Gain?

Can GLP-1 Agonists Be Used to Address Metabolic Dysfunction in Non-Diabetic Individuals?

What Are the Ethical Considerations for Dietary Counseling with Semaglutide?

How Do Dietary Adjustments Impact Semaglutide Efficacy?

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