What is the Origin of Satiety Peptides?

This term is a cornerstone of gastrointestinal endocrinology and metabolism research, following the identification of gut hormones that communicate the state of energy stores to the central nervous system. Satiety refers to the feeling of fullness and the absence of hunger. Key examples include Cholecystokinin (CCK), Glucagon-like peptide-1 (GLP-1), and Peptide YY (PYY).

What is the Mechanism of Satiety Peptides?

Upon food consumption, these peptides are released from enteroendocrine cells into the circulation, acting on specific receptors in the brain, particularly in the hypothalamus and brainstem. For instance, GLP-1 binds to its receptor to enhance the feeling of fullness, slow gastric emptying, and potentiate glucose-dependent insulin secretion. This coordinated action integrates peripheral nutrient status with central appetite control, establishing a powerful feedback loop for energy homeostasis.

Satiety Peptides

Meaning

Satiety peptides are a group of polypeptide hormones secreted primarily by the gastrointestinal tract and adipose tissue in response to nutrient ingestion, signaling to the brain to terminate feeding behavior. These chemical messengers are integral to the short-term and long-term regulation of energy balance and body weight. Clinical interventions often target these peptides to manage appetite and treat metabolic disorders.