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Satiety Hormone Signaling

Meaning

Satiety Hormone Signaling refers to the complex neuroendocrine communication network by which peripheral hormones released from the gastrointestinal tract and adipose tissue transmit messages of fullness to the central nervous system, primarily the hypothalamus. Key hormonal messengers involved include leptin, cholecystokinin (CCK), peptide YY (PYY), and glucagon-like peptide-1 (GLP-1). This intricate signaling cascade is fundamental to the homeostatic regulation of appetite, energy balance, and the maintenance of a stable body weight. Efficient signaling ensures appropriate termination of food intake and the long-term equilibrium of energy stores.