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Satiety Hormone Dysfunction

Meaning

Satiety Hormone Dysfunction describes a pathological state where the regulatory signaling of hormones responsible for inducing the feeling of fullness, or satiety, is impaired, leading to dysregulated energy intake and potential weight gain. This dysfunction can manifest as an inadequate post-prandial secretion of gut-brain peptides like PYY and GLP-1, or, more commonly, as a state of receptor insensitivity or resistance to the adipokine hormone leptin. This impairment disrupts the crucial homeostatic feedback loop that balances energy consumption with energy expenditure. Clinical intervention focuses on restoring the sensitivity and proper communication of this essential endocrine signaling system.