What is the Origin of SASP Suppression?

This concept is central to the emerging field of senolytics and geroscience, which studies the biological mechanisms of aging and seeks to intervene at the cellular level. The discovery of SASP elucidated a major pathway by which a small number of senescent cells can negatively impact surrounding healthy tissue and accelerate age-related pathologies.

What is the Mechanism of SASP Suppression?

Suppression is achieved by targeting the molecular pathways that activate the SASP gene expression program within senescent cells, notably the NF-κB pathway. Senolytic agents work by selectively inducing apoptosis in the senescent cells, thereby eliminating the source of the SASP. Other strategies involve using senomorphic compounds that inhibit the secretion of the inflammatory SASP factors without killing the cell, thus neutralizing its detrimental paracrine effects on the tissue microenvironment.

SASP Suppression ∞ Area

SASP Suppression

Meaning

The clinical and molecular strategy aimed at inhibiting or reducing the production and secretion of the Senescence-Associated Secretory Phenotype (SASP) by senescent cells. SASP is a complex mixture of pro-inflammatory cytokines, chemokines, and matrix metalloproteinases that drives chronic systemic inflammation and tissue dysfunction. Suppression is a key longevity intervention to mitigate the detrimental effects of cellular aging.