What is the Origin of Sarcoplasmic Reticulum ATPase?

This enzyme is a key component of muscle physiology, central to the process of excitation-contraction coupling. The term combines the location, sarcoplasmic reticulum, with its function as an ATPase, an enzyme that hydrolyzes ATP. The discovery and characterization of SERCA elucidated the precise molecular mechanism by which muscle cells actively restore their resting state.

What is the Mechanism of Sarcoplasmic Reticulum ATPase?

SERCA operates as a P-type ATPase, meaning it uses the energy derived from hydrolyzing one molecule of ATP to actively transport two calcium ions against a steep concentration gradient. During muscle contraction, calcium is released into the cytosol, initiating the process. SERCA's action then rapidly lowers the cytosolic calcium concentration, causing the calcium-dependent regulatory proteins to release their hold on the contractile filaments, thereby allowing the muscle to relax.

Sarcoplasmic Reticulum ATPase ∞ Area

Sarcoplasmic Reticulum ATPase

Meaning

Sarcoplasmic Reticulum ATPase, commonly known as SERCA, is a specialized transmembrane enzyme located in the sarcoplasmic reticulum (SR) of muscle cells, where it plays a critical role in muscle relaxation. It functions as a powerful calcium pump, actively sequestering calcium ions from the cytosol back into the SR lumen. This rapid removal of calcium is the decisive event that terminates muscle contraction and prepares the fiber for the next cycle. SERCA activity is essential for both the speed and force of muscle performance.

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HRTioJuly 19, 2025

Sarcoplasmic Reticulum ATPase

Meaning

Origin

Mechanism

How Do Growth Hormone Releasing Peptides Influence Myocardial Contractility and Vascular Tone?

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