A multi-faceted clinical and lifestyle strategy aimed at simultaneously mitigating the age-related loss of skeletal muscle mass (sarcopenia) and the pathological increase in body fat mass (obesity). This prevention requires a synergistic approach combining specific nutritional intake, resistance training, and hormonal optimization to maintain a healthy body composition. It is a critical focus for promoting functional independence and metabolic health in later life.
Origin
This concept emerged from the intersection of geriatrics, endocrinology, and exercise science, recognizing that the co-existence of sarcopenia and obesity creates a particularly detrimental health state. The strategy emphasizes ‘Prevention’ because the combined condition significantly accelerates frailty and metabolic dysfunction, making early intervention essential. It is a key area in healthy aging research.
Mechanism
Prevention is achieved by stimulating muscle protein synthesis while simultaneously improving metabolic flexibility and energy expenditure. Resistance training provides the mechanical stimulus necessary to counteract sarcopenia, while adequate protein intake supplies the necessary amino acid building blocks. Concurrently, managing insulin resistance and optimizing anabolic hormones like testosterone and growth hormone ensures that energy partitioning favors muscle accrual over fat storage.
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