Sarcopenia Treatment encompasses a multifaceted clinical strategy aimed at preventing, slowing, or reversing the progressive, age-related loss of skeletal muscle mass, strength, and function. This condition significantly impacts mobility, metabolic health, and overall quality of life. Effective treatment integrates resistance training, targeted nutritional support, and the optimization of key anabolic hormones.
Origin
The term and its associated clinical focus emerged from the recognition of sarcopenia as a distinct, serious geriatric syndrome with profound public health implications. Its etymology combines the Greek words sarx (flesh) and penia (lack or poverty). Modern treatment protocols have evolved from simple exercise recommendations to complex hormonal and molecular interventions based on a deeper understanding of muscle protein turnover and endocrine signaling.
Mechanism
The therapeutic mechanism relies heavily on stimulating muscle protein synthesis (MPS) and inhibiting muscle protein breakdown (MPB). Resistance exercise provides the mechanical stimulus, while nutritional interventions ensure adequate protein and amino acid availability. Hormonal optimization, often involving Growth Hormone, Insulin-like Growth Factor 1 (IGF-1), and testosterone, is critical for shifting the body into a net anabolic state, thereby promoting myofiber hypertrophy and improving neuromuscular function.
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