What is the Meaning of Sarcopenia Prevention?

Sarcopenia Prevention is a proactive clinical strategy focused on mitigating the progressive, age-related loss of skeletal muscle mass, strength, and functional quality. This intervention is crucial for maintaining metabolic health, mobility, and overall longevity, as sarcopenia is intrinsically linked to frailty, falls, and insulin resistance. The strategy involves a synergistic combination of targeted nutritional support, resistance exercise, and the strategic modulation of anabolic hormonal signaling pathways.

What is the Origin of Sarcopenia Prevention?

The term is derived from the Greek words sarx (flesh) and penia (loss), originally coined in the late 1980s to describe the clinical syndrome of muscle wasting in older adults. Its prevention has become a central focus of longevity medicine due to the profound endocrine and metabolic changes that accompany aging, specifically the decline in anabolic hormones. The focus shifted from treating frailty to proactively preserving lean body mass.

What is the Mechanism of Sarcopenia Prevention?

Prevention operates primarily by enhancing muscle protein synthesis (MPS) and inhibiting muscle protein breakdown. Hormonal interventions target the age-related decline in anabolic signals, notably testosterone, growth hormone (GH), and Insulin-like Growth Factor-1 (IGF-1). Testosterone and estrogen act via their respective receptors on muscle cells to promote hypertrophy and reduce inflammatory catabolism. The protocol typically integrates resistance training, which sensitizes muscle tissue to these anabolic signals, maximizing the hormonal drive for muscle maintenance and functional strength.

Sarcopenia Prevention ∞ Area ∞ Library 22

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