Sarcopenia Prevention Strategies encompass clinical and lifestyle modalities specifically implemented to counteract the age-related, progressive loss of skeletal muscle mass and strength, which significantly impacts metabolic health and functional independence. These strategies must address anabolic resistance and mitigate catabolic signaling prevalent in aging physiology. Effective prevention is crucial for maintaining long-term mobility.
Origin
The term combines ‘sarcopenia,’ derived from Greek meaning ‘flesh wasting,’ with ‘prevention strategies,’ indicating planned countermeasures against this condition. It is a core concept in geriatric endocrinology and functional longevity.
Mechanism
The primary mechanism involves optimizing anabolic hormone signaling, particularly ensuring adequate testosterone and growth hormone/IGF-1 axis activity to promote muscle protein synthesis. Resistance training provides the necessary mechanical stimulus, while ensuring sufficient amino acid availability, especially leucine, supports the mTOR pathway activation required for hypertrophy. These integrated actions overcome the physiological hurdles that lead to muscle fiber atrophy.
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