Sarcopenia Mitigation Strategies are comprehensive clinical and lifestyle interventions specifically designed to prevent, slow, or reverse the progressive, age-related loss of skeletal muscle mass, strength, and function. These strategies address the multifactorial etiology of sarcopenia, which includes hormonal decline, chronic inflammation, decreased physical activity, and nutritional insufficiency. Successful mitigation is paramount for maintaining physical independence, metabolic health, and reducing the risk of falls and fractures in the aging population. It is a core pillar of longevity medicine.
Origin
The term “sarcopenia,” derived from the Greek sarx (flesh) and penia (lack), was coined in 1989 to describe this syndrome. Mitigation strategies emerged as clinical recognition of the condition shifted from an inevitable consequence of aging to a treatable pathology. The protocols integrate established principles of geriatrics, endocrinology, and exercise science to combat muscle atrophy and functional decline.
Mechanism
The primary mechanisms of mitigation involve restoring the anabolic drive and providing the necessary substrate and stimulus for muscle maintenance. This includes optimizing levels of anabolic hormones such as testosterone, estrogen, and Growth Hormone/IGF-1, which enhance muscle protein synthesis and satellite cell activity. Concurrently, implementing resistance training provides the mechanical tension signal, while ensuring adequate, high-quality protein intake supplies the necessary amino acid building blocks for hypertrophy and repair.
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