Sarcopenia mitigation refers to the clinical and lifestyle strategies employed to prevent or slow the progressive, age-related loss of skeletal muscle mass and strength, a condition known as sarcopenia. Effective mitigation is critical for maintaining physical function, metabolic health, and quality of life in older adults, as muscle tissue is a primary site of glucose disposal and hormonal action. This proactive approach supports musculoskeletal and endocrine integrity.
Origin
The term combines ‘sarcopenia,’ derived from the Greek sarx (flesh) and penia (loss or deficiency), with ‘mitigation,’ meaning the action of reducing the severity of something. The recognition of sarcopenia as a distinct clinical entity has driven research into preventative and therapeutic strategies.
Mechanism
Mitigation strategies primarily involve optimizing anabolic signaling pathways through a combination of progressive resistance exercise, which provides a mechanical stimulus for muscle protein synthesis, and targeted nutritional intervention, particularly adequate protein and specific amino acid intake. Furthermore, optimizing key anabolic hormones, such as testosterone and growth hormone, through bioidentical hormone therapy can significantly enhance the body’s capacity for muscle tissue repair and maintenance.
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