What is the Origin of SAMe?

SAMe is derived biologically from the essential amino acid methionine via the action of methionine adenosyltransferase. It is a universal cofactor found in nearly all tissues, underscoring its fundamental role in cellular maintenance and metabolism. Its biochemical importance transcends any single physiological system.

What is the Mechanism of SAMe?

SAMe drives the methylation cycle, which is necessary for synthesizing phosphatidylcholine, creatine, and key catecholamine neurotransmitters like dopamine and norepinephrine. Crucially, it participates in DNA and protein methylation, epigenetic modifications that dictate which genes are expressed or silenced. Adequate SAMe is therefore necessary for optimal endocrine receptor function and cellular repair.

SAMe

Meaning

SAMe, or S-adenosylmethionine, is an endogenous sulfonium compound functioning as a critical methyl donor required for over one hundred distinct enzymatic reactions within human physiology. This molecule is central to numerous biosynthetic pathways, including the creation of critical signaling molecules. Its availability directly impacts methylation status across the genome.