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Salivary Cortisol Profiling

Meaning

Salivary Cortisol Profiling is a non-invasive clinical diagnostic technique that measures the concentration of free, biologically active cortisol in saliva at multiple, specific time points throughout the day. This profiling provides a dynamic assessment of the hypothalamic-pituitary-adrenal (HPA) axis function, revealing the circadian rhythm, the cortisol awakening response (CAR), and the overall diurnal slope. It is a precise tool for evaluating stress adaptation, adrenal reserve, and HPA axis dysregulation, offering more functional insight than a single static measurement.