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S-Adenosylmethionine

Meaning

S-Adenosylmethionine (SAMe) is a crucial, naturally occurring molecule synthesized in the body from the essential amino acid methionine and ATP, serving as the primary universal methyl donor in countless biochemical reactions. SAMe is indispensable for the process of methylation, a fundamental biochemical reaction required for the synthesis, metabolism, and breakdown of hormones, neurotransmitters, and DNA. Clinically, SAMe levels are vital for liver detoxification, mood regulation, and joint health. Its role in estrogen metabolism pathways, specifically the methylation of catechol estrogens, makes it a key player in hormonal balance and cellular protection.