Skip to main content

S-adenosyl-L-methionine

Meaning

S-adenosyl-L-methionine (SAMe) is a crucial, naturally occurring metabolite present in all living cells, serving as the principal methyl donor for numerous biochemical reactions. This molecule is essential for a vast array of physiological processes, including the synthesis of neurotransmitters, hormones, phospholipids, and nucleic acids, as well as the regulation of gene expression through epigenetic methylation. Clinically, SAMe is recognized for its roles in liver health, mood regulation, and joint function, highlighting its fundamental importance in maintaining cellular homeostasis and metabolic integrity. It is a central nexus in the body’s one-carbon metabolism.