What is the Origin of Rs6258?

The term is a nomenclature assigned by the National Center for Biotechnology Information (NCBI) to catalog a specific genetic variant. The 'rs' prefix stands for 'Reference SNP', a standardized identifier for human genetic variation. Its clinical relevance lies within the field of pharmacogenomics and hormonal health, where genetic predisposition influences an individual's endocrine status.

What is the Mechanism of Rs6258?

The SNP Rs6258 is believed to affect the expression or regulation of the SHBG gene, potentially altering the quantity of the protein synthesized by the liver and released into the circulation. Since SHBG binds with high affinity to sex steroids, changes in its concentration directly modulate the free, biologically active fraction of these hormones available to target tissues. Therefore, this polymorphism contributes to individual differences in androgen or estrogen activity, impacting metabolic and reproductive health outcomes.

Rs6258 ∞ Area

Rs6258

Meaning

Rs6258 is a specific single-nucleotide polymorphism (SNP) identified by its unique reference number in the dbSNP database, a key resource in human genetics. This common genetic variation is located within the gene encoding the Sex Hormone-Binding Globulin (SHBG) protein. The presence of a particular allele at this locus is consistently associated with variations in circulating SHBG levels, which consequently influences the bioavailability of sex hormones like testosterone and estradiol.