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Rs1360780

Meaning

Rs1360780 is a single nucleotide polymorphism (SNP) located in the FKBP5 gene on chromosome 6, representing a common genetic variation that has been consistently linked to altered sensitivity of the glucocorticoid receptor (GR) and a predisposition to stress-related disorders. This specific SNP is an A-to-G substitution that influences the gene’s expression, ultimately leading to higher levels of the FKBP51 protein. The presence of the G allele is associated with a less sensitive GR, resulting in a less effective negative feedback loop on the HPA axis following stress exposure.