Skip to main content

Rhythmic Hormone Replacement

Meaning

Rhythmic Hormone Replacement is a clinical strategy that administers exogenous hormones in a pattern designed to closely mimic the natural, pulsatile, and circadian or infradian rhythms of endogenous hormone secretion. This approach moves beyond static, steady-state dosing to re-establish the crucial temporal signaling necessary for optimal health, function, and receptor sensitivity. For instance, this therapy involves administering cortisol in a morning-dominant curve or sex hormones in a cycle-mimicking cadence. The primary objective is to restore the body’s natural hormonal communication, minimizing side effects and maximizing the long-term physiological benefits of the replacement.