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Reversing Cellular Senescence

Meaning

Reversing Cellular Senescence is a clinical and scientific objective focused on eliminating or functionally rejuvenating senescent cells, which are cells that have permanently ceased dividing but remain metabolically active and secrete pro-inflammatory molecules known as the Senescence-Associated Secretory Phenotype (SASP). Senescent cells accumulate with age and contribute significantly to tissue dysfunction, chronic inflammation, and the pathology of multiple age-related diseases. Therapeutic strategies aim to clear these detrimental cells or reprogram them to a non-senescent state, thereby improving tissue function and extending healthspan. This is a direct intervention into a fundamental mechanism of biological aging.