Reverse T3 Dominance

Meaning

Reverse T3 Dominance is a clinical presentation characterized by elevated levels of reverse triiodothyronine (rT3), an inactive metabolite of the primary thyroid hormone thyroxine (T4), relative to the active thyroid hormone triiodothyronine (T3). This condition indicates a state where the body preferentially shunts T4 into the inactive rT3 pathway, often in response to physiological stress, chronic illness, or caloric restriction, effectively creating a state of functional hypothyroidism at the cellular level despite normal TSH or T4 levels.

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